Difference Between Abo And Rh Incompatibility Pdf

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06.05.2021 at 05:54
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difference between abo and rh incompatibility pdf

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Correspondence Address : Dr. Context: ABO blood group antigens are inherited and specific to an individual. In pregnancy, active immunisation occurs when the foetus is of a different ABO blood group from the mother and may result in neonatal jaundice NNJ.

Management of Pregnancy with ABO Incompatibility

The Rh factor is a protein that can be found on the surface of red blood cells. If your blood cells have this protein, you are Rh positive. If your blood cells do not have this protein, you are Rh negative. During pregnancy, problems can occur if you are Rh negative and your fetus is Rh positive. Treatment can be given to prevent these problems. The Rh factor is inherited, meaning it is passed from parent to child through genes.


Coronavirus Guidelines. Visit free Relief Central. Prime PubMed is provided free to individuals by: Unbound Medicine. Rh Incompatibility. The reason for reporting this case is to remind that some microorganisms may cause hemolysis leading to early and severe hyperbilirubinemia by secreting hemolysin in cases; where bilirubin levels cannot be successfully decreased despite effective phototherapy, intravenous immunoglobulin, and even exchange transfusion, or in cases of increased rebound bilirubin although urinary tract infection is associated with increased conjugated bilirubin fraction and prolonged jaundice. Anti-D is the most common cause of hemolytic disease of the newborn HDN in the developing countries even after the introduction of anti-D immunoprophylaxis.

Occurrence of ABO And RhD Incompatibility with Rh Negative Mothers

Hemolytic disease of the newborn was first described in the medical literature , when it was diagnosed in one French housewife. In Diamond and colleagues described the mutual relationship of fetal hydrops, jaundice, anemia and erythoblastosis, which was later called fetal erytroblastosis. Immune alloantibodies were detected in vivo by indirect Coombs test ICT with serum mother and O test erythrocytes, by direct Coombs test DCT with erythrocytes of a newborn. Most of immune antibodies appear in mothers with O Rh D: negative blood type.

ABO incompatibility is one of the diseases which can cause jaundice. It happens when a mother's blood type is O, and her baby's blood type is A or B. The mother's immune system may react and make antibodies against her baby's red blood cells.

Registered users can also download a PDF or listen to a podcast of this Pearl. Log in now , or create a free account to access bonus Pearls features. ABO incompatibility is the most common maternal-fetal blood group incompatibility and the most common cause of hemolytic disease of the newborn HDN.


The ABO blood group system is the best known surface antigen system, expressed on a wide variety of human cells. In about a third of all ABO incompatible pregnancies maternal IgG anti-A or IgG anti-B antibodies pass through the placenta to the fetal circulation leading to a weakly positive direct Coombs test for the neonate's blood. The antibodies in ABO HDN cause anemia due to destruction of fetal red blood cells and jaundice due to the rise in blood levels of bilirubin a by-product of hemoglobin break down. If the anemia is severe, it can be treated with a blood transfusion, however this is rarely needed. On the other hand, neonates have underdeveloped livers that are unable to process large amounts of bilirubin and a poorly developed blood-brain barrier that is unable to block bilirubin from entering the brain.

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06.05.2021 at 16:26 - Reply

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PDF | ABO incompatibility is one of the most common cause of haemolytic disease of fetus and new-born Table 1: Comparison of Rh and ABO incompatibility.

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12.05.2021 at 02:23 - Reply

PDF | Hemolytic disease of the newborn was first described in the medical literature , when it was diagnosed in one French housewife.

Eric I.
13.05.2021 at 18:40 - Reply

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